The progression of carotid atherosclerosis and imaging markers of dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions

Jayandra J. Himali¹  Alexa Beiser¹  Serkalem Demissie¹  Sudha Seshadri²  Jose R. Romero²  Charles DeCarli³  Joseph F. Polak⁴  Hediyeh Baradaran⁵  Ajay Gupta⁶ 

[1] Department of Biostatistics Boston University School of Medicine Boston Massachusetts USA;Department of Neurology Boston University School of Medicine Boston Massachusetts USA;Department of Neurology University of California‐Davis Sacramento California USA;Department of Radiology Tufts University School of Medicine Boston Massachusetts USA;Department of Radiology University of Utah Salt Lake City Utah USA;Department of Radiology Weill Cornell Medicine New York New York USA;

关键词: atherosclerosis;    carotid artery;    carotid ultrasound;    hippocampus;    magnetic resonance imaging;   

DOI  :  10.1002/trc2.12015

来源: DOAJ

【 摘 要 】

Abstract Introduction We studied the association of carotid intima‐media thickness (CIMT) with hippocampal volume (HV) in community dwelling individuals, testing the hypothesis that persons with carotid atherosclerosis progression would have lower HV. Methods We studied 1376 Framingham Offspring participants with two carotid ultrasounds and brain magnetic resonance imaging (MRIs). We used multivariable linear regression analyses to relate CIMT progression and HV and total brain volume. Regression models were adjusted for demographics and vascular risk factors, time interval between imaging examinations, and baseline CIMT. We assessed effect modification by hypertension treatment (HRx). Results Participants with higher ICA IMT progression had significantly lower HV after adjustment for vascular risk factors and baseline IMT (standardized beta ± standard error: −0.067 ± 0.027, P = .01). We observed weaker association between ICA IMT change and HV among subjects treated for hypertension (β = −0.047, P = .19 vs β = −0.096, P = .026). Discussion Cumulative vascular risk factor exposure, reflected by CIMT progression, may increase the risk of neurodegeneration.

【 授权许可】

Unknown