Prognostic value of immune-related lncRNA pairs in patients with bladder cancer

World Journal of Surgical Oncology

Faming Fei¹  Peng Fu¹  Dongjuan Wu¹  Zhenzhen Gao¹  Lianhong Yuan²  Taohong Zhu³  Wenwen Zheng³  Ting Sun³ 

[1] Department of Clinical Oncology, The Second Affiliated Hospital of Jiaxing University;Department of General Medicine, Nanhu District Central Hospital of Jiaxing;Jiaxing hospice and palliative care center, The second affiliated hospital of Jiaxing;

关键词: Bladder cancer;    Immunotherapy;    Long non-coding RNA;    Risk model;    Prognosis;   

DOI  :  10.1186/s12957-021-02419-8

来源: DOAJ

【 摘 要 】

Abstract Background The characteristics of immune-related long non-coding ribonucleic acids (ir-lncRNAs), regardless of their specific levels, have important implications for the prognosis of patients with bladder cancer. Methods Based on The Cancer Genome Atlas database, original transcript data were analyzed. The ir-lncRNAs were obtained using a coexpression method, and their differentially expressed pairs (DE-ir-lncRNAs) were identified by univariate analysis. The lncRNA pairs were verified using a Lasso regression test. Thereafter, receiver operating characteristic curves were generated, and an optimal risk model was established. The clinical value of the model was verified through the analysis of patient survival rates, clinicopathological characteristics, presence of tumor-infiltrating immune cells, and chemotherapy efficacy evaluation. Results In total, 49 pairs of DE-ir-lncRNAs were identified, of which 21 were included in the Cox regression model. A risk regression model was established on the premise of not involving the specific expression value of the transcripts. Conclusions The method and model used in this study have important clinical predictive value for bladder cancer and other malignant tumors.

【 授权许可】

Unknown