The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)

Cells

Michał K. Zarobkiewicz¹  Agnieszka A. Bojarska-Junak¹ 

[1] Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland;

关键词: γδ T;    Vδ1;    Vδ2;    Vδ3;    CLL;    chronic lymphocytic leukaemia;   

DOI  :  10.3390/cells11040661

来源: DOAJ

【 摘 要 】

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among adults. It is the clonal expansion of B cells expressing CD19 and CD5. Despite significant progress in treatment, CLL is still incurable. γδ T cells comprise an important subset of the cytotoxic T cells. Although γδ T cells in CLL are dysfunctional, they still can possibly be used for immunotherapy. The current paper reviews our understanding of γδ T lymphocytes in CLL.

【 授权许可】

Unknown