Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid‐positive individuals

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Serge Gauthier¹  Eduardo R. Zimmer¹  Antoine Leuzy²  Aurélie Labbe³  Henrik Zetterberg⁴  Michael Schöll⁴  Nicholas J. Ashton⁴  Kaj Blennow⁴  Sulantha Mathotaarachchi⁵  Min S. Kang⁵  Joseph Therriault⁵  Mira Chamoun⁵  Andréa L. Benedet⁵  Pedro R. Neto⁵  Melissa Savard⁵  Alzheimer's Disease Neuroimaging Initiative⁵  Tharick A. Pascoal⁵ 

[1]Alzheimer's Disease Research UnitThe McGill University Research Centre for Studies in Aging, Montreal, McGill UniversityMontrealQuebecCanada

[2]Clinical Memory Research UnitDepartment of Clinical Sciences, MalmöLund UniversityLundSweden

[3]Department of Decision SciencesHEC MontrealMontrealQuebecCanada

[4]Department of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgMölndalSweden

[5]Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, McGill UniversityMontrealQuebecCanada

关键词: Neurofilament light;    Hypometabolism;    [18F]FDG;    Neurodegeneration;    Alzheimer's disease;    Biomarkers;   

DOI  :  10.1016/j.dadm.2019.08.002

来源: DOAJ

【 摘 要 】

Abstract Introduction Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods Voxelwise regression models tested the cross‐sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD‐vulnerable regions. Longitudinal changes in the association [18F]FDG‐NfL were confined to cognitively impaired Aβ+ individuals. Discussion These findings indicate that plasma NfL is a proxy for neurodegeneration in AD‐related regions in Aβ+ subjects.

【 授权许可】

Unknown