Mechanisms of Copper Homeostasis in Bacteria

Frontiers in Cellular and Infection Microbiology

Daniel eRaimunda¹  Jose Martin Arguello²  Teresita ePadilla-Benavides² 

[1] Instituto de Investigación Médica M. y M. Ferreyra;Worcester Polytechnic Institute;

关键词: Copper;    Homeostasis;    Metallochaperones;    Metalloenzymes;    transmembrane transport;    Cu+-ATPases.;   

DOI  :  10.3389/fcimb.2013.00073

来源: DOAJ

【 摘 要 】

Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.

【 授权许可】

Unknown