Prenatal Particulate Matter (PM) Exposure and Natriuretic Peptides in Newborns from Mexico City

International Journal of Environmental Research and Public Health

Andrés Eduardo Nepomuceno-Hernández¹  Rodrigo Ayala-Yáñez¹  Monserrat Sordo²  Abigail Muñoz-Rodríguez²  Jorge H. Limón-Pacheco²  María Eugenia Gonsebatt²  Citlalli Osorio-Yáñez²  Ana María Salazar²  Patricia Ostrosky-Wegman²  Jorge Alfonso Maciel-Ruiz³ 

[1] Centro de Investigación Materno Infantil del Grupo de Estudios al Nacimiento, Asociación Hispano Mexicana, Ciudad de México 09880, Mexico;Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico;Instituto Nacional de Cancerología (INCan), Subdirección de Investigación Básica, Ciudad de México 14080, Mexico;

关键词: air pollution;    particulate matter exposure;    pregnancy;    natriuretic peptides;    newborns;    ANP;   

DOI  :  10.3390/ijerph18126546

来源: DOAJ

【 摘 要 】

(1) Background: The aim of this study was to assess associations between particulate matter (PM) exposure and natriuretic peptide concentrations in cord blood from newborns. (2) Methods: we conducted a cross-sectional study in Mexico City with 101 pregnant women from CIMIGEN Hospital. Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were measured in plasma from cord blood in 51 newborns by ELISA. We estimated PM exposure (PM2.5 and PM10) at first, second and third trimester of pregnancy. (3) Results: The median and interquartile range for ANP, BNP and CNP plasma concentrations were 66.71 (46.92–80.23), 98.23 (73.64–112.30) and 1129.11 (944.10–1452.02) pg/mL, respectively. PM2.5 and PM10 levels for the whole pregnancy period were 22.2 µg/m³ and 41.63 µg/m³, respectively. Employing multivariable linear regression models adjusted for maternal age, newborn sex, smoking before pregnancy, maternal occupation and newborns’ length and height, we observed a 2.47 pg/mL (95%CI: −4.67, −0.27) decrease in BNP associated with PM2.5 exposure during second trimester. Adjusted for the same set of confounders, third trimester PM10 exposure was inversely associated with ANP concentrations (beta estimate: −0.90; 95% CI: −1.80, −0.03). Neither PM10 nor PM2.5 were associated with CNP at any trimester of pregnancy. (4) Conclusions: Prenatal exposure to particulate matter was associated with ANP and BNP decrease in newborns.

【 授权许可】

Unknown