Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer

Diagnostics

Clara Musicco¹  Antonella Cormio²  Claudia Piccoli³  Francesca Sanguedolce⁴  Giuseppe Carrieri⁵  Ugo Giovanni Falagario⁵  Luigi Cormio⁵  Gian Maria Busetto⁵  Marco Chirico⁵  Beppe Calò⁶ 

[1] CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70126 Bari, Italy;Department of Biosciences, Biotechnologies, and Biofarmaceutical, University of Bari, 70126 Bari, Italy;Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy;Department of Pathology, University of Foggia, 71122 Foggia, Italy;Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy;Department of Urology, Bonomo Hospital, 76123 Andria, Italy;

关键词: bladder cancer;    NMIBC;    Mfn2;    ClpP;    disease progression;    disease recurrence;   

DOI  :  10.3390/diagnostics11081500

来源: DOAJ

【 摘 要 】

Identification of markers predicting disease outcome is a major clinical issue for non-muscle invasive bladder cancer (NMIBC). The present study aimed to determine the role of the mitochondrial proteins Mitofusin-2 (Mfn2) and caseinolytic protease P (ClpP) in predicting the outcome of NMIBC. The study population consisted of patients scheduled for transurethral resection of bladder tumor upon the clinical diagnosis of bladder cancer (BC). Samples of the main bladder tumor and healthy-looking bladder wall from patients classified as NMIBC were tested for Mfn2 and ClpP. The expression levels of these proteins were correlated to disease recurrence, progression. Mfn2 and ClpP expression levels were significantly higher in lesional than in non-lesional tissue. Low-risk NMIBC had significantly higher Mfn2 expression levels and significantly lower ClpP expression levels than high-risk NMIBC; there were no differences in non-lesional levels of the two proteins. Lesional Mfn2 expression levels were significantly lower in patients who progressed whereas ClpP levels had no impact on any survival outcome. Multivariable analysis adjusting for the EORTC scores showed that Mfn2 downregulation was significantly associated with disease progression. In conclusion, Mfn2 and ClpP proteins were found to be overexpressed in BC as compared to non-lesional bladder tissue and Mfn2 expression predicted disease progression.

【 授权许可】

Unknown