Asymptomatic Strongyloidiasis among Latin American Migrants in Spain: A Community-Based Approach

Pathogens

Corazones Sin Chagas Platform¹  José-Manuel Ramos-Rincón²  María Flores-Chávez³  Diego Torrús-Tendero⁴  Violeta Ramos-Sesma⁵  Concepción Amador-Prous⁶  Ana-María Garijo-Sainz⁶  Antonio Santonja⁶  Ana-Isabel Pujades-Tárraga⁶  Concepción Gil-Anguita⁶  Philip Wikman-Jorgensen⁷  Cristina Bernal-Alcaraz⁸  Jara Llenas-García⁸  María García-López⁸  Pedro Guevara-Hernández⁸  María-Paz Ventero-Martín⁹  José-María Saugar^1,10  Miriam Navarro^1,11 

[1] ;Clinica Medicine Department, University Miguel Hernández de Elche, 03550 Sant Joan d’Alacant, Alicante, Spain;Foundation Mundo Sano, 28046 Madrid, Spain;Internal Medicine Service, General University Hospital of Alicante-ISABIAL, 03550 Alicante, Spain;Internal Medicine Service, HLA Inmaculada Hospital, 18004 Granada, Spain;Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain;Internal Medicine Service, University Clinical Hospital Sant Joan d’Alacant-FISABIO, 03550 Alicante, Spain;Internal Medicine Service, Vega Baja Hospital-FISABIO, Orihuela, 03314 Alicante, Spain;Microbiology Service, General University Hospital of Alicante -ISABIAL, 03010 Alicante, Spain;Parasitology Service, National Center of Microbiology, 28222 Madrid, Spain;Public Health, Science History and Gynecology Department, Universidad Miguel Hernández, 03550 Sant Joan d’Alacant, Alicante, Spain;

关键词: Strongyloidiasis;    Strongyloides stercoralis;    Chagas disease;    Central and South America;    Community-based intervention;    migrants;   

DOI  :  10.3390/pathogens9060511

来源: DOAJ

【 摘 要 】

Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic. Aim: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain. Methodology: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany). Results: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases. Conclusion: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients’ adherence to the medical follow-up.

【 授权许可】

Unknown