Gut associated metabolites and their roles in Clostridioides difficile pathogenesis

Gut Microbes

Andrea Martinez Aguirre¹  Joseph A. Sorg² 

[1] Department of Biology, Texas A&M University, College Station, TX, USA;

关键词: Clostridioides difficile;    gut metabolites;    microbiome;    fecal microbial therapy;    bile acids;    Stickland;   

DOI  :  10.1080/19490976.2022.2094672

来源: DOAJ

【 摘 要 】

The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut microbiota have been shown to interact with C. difficile. Certain bile acids promote/inhibit germination while other cholesterol-derived compounds and amino acids used in the Stickland metabolic pathway affect growth and CDI colonization. Short chain fatty acids maintain intestinal barrier integrity and a myriad of other metabolic compounds are used as nutritional sources or used by C. difficile to inhibit or outcompete other bacteria in the gut. As the move toward non-antibiotic CDI treatment takes place, a deeper understanding of interactions between C. difficile and the host’s gut microbiome and metabolites becomes more relevant.

【 授权许可】

Unknown