Myosin XVI in the Nervous System

Cells

Beáta Bugyi¹  Elek Telek¹  András Kengyel¹ 

[1] Department of Biophysics, Medical School, University of Pécs, Szigeti str. 12, H-7624 Pécs, Hungary;

关键词: neural;    development;    myosin;    mammalian;    unconventional;    myosin XVI;   

DOI  :  10.3390/cells9081903

来源: DOAJ

【 摘 要 】

The myosin family is a large inventory of actin-associated motor proteins that participate in a diverse array of cellular functions. Several myosin classes are expressed in neural cells and play important roles in neural functioning. A recently discovered member of the myosin superfamily, the vertebrate-specific myosin XVI (Myo16) class is expressed predominantly in neural tissues and appears to be involved in the development and proper functioning of the nervous system. Accordingly, the alterations of MYO16 has been linked to neurological disorders. Although the role of Myo16 as a generic actin-associated motor is still enigmatic, the N-, and C-terminal extensions that flank the motor domain seem to confer unique structural features and versatile interactions to the protein. Recent biochemical and physiological examinations portray Myo16 as a signal transduction element that integrates cell signaling pathways to actin cytoskeleton reorganization. This review discusses the current knowledge of the structure-function relation of Myo16. In light of its prevalent localization, the emphasis is laid on the neural aspects.

【 授权许可】

Unknown