Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation

Acta Pharmaceutica

Aouad Mohamed Reda¹  Rezki Nadjet¹ 

[1] Department of Chemistry, Faculty of Sciences, Taibah University, PO Box 344, Al-Madinah, Al-Munawarah, Saudi Arabia;

关键词: benzothiazoles;    1,2,3-triazoles;    1,2,4-triazoles;    click synthesis;    antimicrobial;   

DOI  :  10.1515/acph-2017-0024

来源: DOAJ

【 摘 要 】

The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the appropriate bromoacetamide benzothiazole, sodium azide and 4-alkyl/aryl-5-(2-fluorophenyl)-3-(prop-2-ynylthio)-1,2,4-triazoles 4a-e through a Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction. This approach involves in situ generation of azidoacetamide benzothiazole, followed by condensation with terminal alkynes in the presence of CuSO4/Na-ascorbate in aqueous DMSO under both conventional and ultrasound conditions. Some of the designed 1,2,3-triazole conjugates 6a-o were recognized for their antimicrobial activity against some bacterial and fungal pathogenic strains.

【 授权许可】

Unknown