P-glycoprotein functional activity and expression in type 2 alloxan diabetes

RUDN Journal of Medicine

A N Ryabkov¹  D S Titov¹  N M Popova¹  E N Yakusheva¹ 

[1] Рязанский государственный медицинский университет им. акад. И.П. Павлова;

关键词: гликопротеин-P;    ABCB1-белок;    функциональная активность;    экспрессия;    аллоксан-индуцированный сахарный диабет 2 типа;   

DOI  :  

来源: DOAJ

【 摘 要 】

On 16 Chinchilla rabbits males of breed with type 2 alloxan diabetes P-glycoprotein functional activity and expression was studied. The diabetes mellitus was modelled by intravenous administration of alloxan monohydrate in the citrate buffer. P-glycoprotein functional activity was assessed by pharmacokinetics of its probe substrate - fexofenadine after its single oral administration. P-glycoprotein expression was investigated by immunohistochemistry method. The inhibition of P-glycoprotein functional activity and expression was followed by decrease of postprandial insulin level and an insulinogenic index and increase of postprandial glucose level in a blood.

【 授权许可】

Unknown