The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders

Frontiers in Psychiatry

Tomoaki Kinukawa¹  Tomoya Taniguchi¹  Eishi Motomura²  Shunsuke Sugiyama³  Yukimasa Muto³  Ayumi Kuramitsu³  Kentaro Takai³  Kazutaka Ohi³  Toshiki Shioiri³  Koji Inui⁴  Nobuyuki Takeuchi⁵  Makoto Nishihara⁶ 

[1] Department of Anesthesiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;Department of Neuropsychiatry, Mie University Graduate School of Medicine, Tsu, Japan;Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan;Departmernt of Functioning and Disability, Institute for Developmental Research, Kasugai, Japan;Depatment of Psychiatry, Aichi Medical University, Nagakute, Japan;Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan;

关键词: ASSR;    gamma-band oscillation;    phase resetting;    electroencephalography;    magnetoencephalography;    schizophrenia;   

DOI  :  10.3389/fpsyt.2021.644541

来源: DOAJ

【 摘 要 】

Sensory processing is disrupted in several psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. In this review, we focus on the electrophysiological auditory steady-state response (ASSR) driven by high-frequency stimulus trains as an index for disease-associated sensory processing deficits. The ASSR amplitude is suppressed within the gamma band (≥30 Hz) among these patients, suggesting an imbalance between GABAergic and N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission. The reduced power and synchronization of the 40-Hz ASSR are robust in patients with schizophrenia. In recent years, similar ASSR deficits at gamma frequencies have also been reported in patients with bipolar disorder and autism spectrum disorder. We summarize ASSR abnormalities in each of these psychiatric disorders and suggest that the observed commonalities reflect shared pathophysiological mechanisms. We reviewed studies on phase resetting in which a salient sensory stimulus affects ASSR. Phase resetting induces the reduction of both the amplitude and phase of ASSR. Moreover, phase resetting is also affected by rare auditory stimulus patterns or superimposed stimuli of other modalities. Thus, sensory memory and multisensory integration can be investigated using phase resetting of ASSR. Here, we propose that ASSR amplitude, phase, and resetting responses are sensitive indices for investigating sensory processing dysfunction in psychiatric disorders.

【 授权许可】

Unknown