Immunotherapies and Combination Strategies for Immuno-Oncology

International Journal of Molecular Sciences

Silvia Jakubski¹  Priyanka Parajuli²  Narottam Lamichhane³  Purushottam Lamichhane⁴  RahulR. Deshmukh⁵  Cody Barbari⁶  Tyler Fontaine⁶ 

[1] Department of Biostatistics, University of Florida, Gainesville, FL 32611, USA;Department of Internal Medicine, Southern Illinois University, Springfield, IL 62702, USA;Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA;LECOM School of Dental Medicine, 4800 Lakewood Ranch Blvd, Bradenton, FL 34211, USA;LECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USA;OMS Students, LECOM School of Osteopathic Medicine, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USA;

关键词: checkpoint inhibition;    immunotherapy;    chemoresistance;    combination therapy;    radiation therapy;    adoptive cell transfer;   

DOI  :  10.3390/ijms21145009

来源: DOAJ

【 摘 要 】

The advent of novel immunotherapies in the treatment of cancers has dramatically changed the landscape of the oncology field. Recent developments in checkpoint inhibition therapies, tumor-infiltrating lymphocyte therapies, chimeric antigen receptor T cell therapies, and cancer vaccines have shown immense promise for significant advancements in cancer treatments. Immunotherapies act on distinct steps of immune response to augment the body’s natural ability to recognize, target, and destroy cancerous cells. Combination treatments with immunotherapies and other modalities intend to activate immune response, decrease immunosuppression, and target signaling and resistance pathways to offer a more durable, long-lasting treatment compared to traditional therapies and immunotherapies as monotherapies for cancers. This review aims to briefly describe the rationale, mechanisms of action, and clinical efficacy of common immunotherapies and highlight promising combination strategies currently approved or under clinical development. Additionally, we will discuss the benefits and limitations of these immunotherapy approaches as monotherapies as well as in combination with other treatments.

【 授权许可】

Unknown