TNF-like ligand 1A is associated with progression and prognosis of human gastric cancer

OncoTargets and Therapy

关键词: TNF-like ligand 1A;    Gastric cancer;    Co-expression analysis;    GSEA;    Prognosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Yaxian Gao,1,2,* Yuanyuan Wang,3,* Xiao Wang,1 Yongwei Wang,4 Xiaoqing Zhang,1 Xun Sun1 1Department of Immunology, China Medical University, Shenyang, Liaoning 110000, People’s Republic of China; 2Department of Immunology, Chengde Medical College, Chengde, Hebei 067000, People’s Republic of China; 3Department of Anesthesiology, The Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning 110000, People’s Republic of China; 4Department of Anatomy, Chengde Medical College, Chengde, Hebei 067000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xun SunDepartment of Immunology, China Medical University, No. 77 Puhe Road, North New Area, Shenyang, Liaoning 110000, People’s Republic of ChinaTel [phone] (ext. 5345)Fax [phone]Email [e-mail]: This study aimed to investigate the function of TNF-like ligand 1A (TL1A) in the tumorigenesis and progression of gastric cancer (GC).Methods: RNA-seq gene expression and clinical information for GC patients were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) between GC tissue samples and normal controls were screened with the edgeR package. Identification of gene co-expression and functional enrichment analyses were performed with Pearson’s correlation analysis and gene set enrichment analysis (GSEA), respectively. Lastly, survival analysis was performed using the Kaplan-Meier method with the log rank test.Results: TL1A expression in GC tissue samples were significantly higher than that in normal controls (LogFC=1.07 and P=8.90E-07). Moreover, 215 genes, co-expressed with TL1A, and 21 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were obtained. Next, the miRNA-lncRNA/mRNA network, comprising 7 miRNAs, 27 lncRNAs, and 21 mRNAs, was constructed based on key genes from intersections between co-expression analysis and GSEA. In addition, survival analysis results demonstrated that TL1A (P=2.6e−07) was significantly associated with the overall survival (OS) of GC patients.Conclusion: TL1A was involved in the tumorigenesis and progression of GC, and was significantly associated with the OS of GC patients.Keywords: TNF-like ligand 1A, gastric cancer, co-expression analysis, GSEA, prognosis

【 授权许可】

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