Associations of sarcopenia and its defining components with cognitive function in community-dwelling oldest old

BMC Geriatrics

Xiao Zou¹  Juan Liu²  Linna Wu³  Li Fan⁴  Weihao Xu⁴  Yixin Hu⁴  Lin Zou⁴  Jing Sun⁴  Yunxia Liu⁴  Jing Zuo⁴  Xinli Deng⁵  Hengge Xie⁶  Xiaohong Zhang⁶  Anying Bai⁷ 

[1] Geriatric Cardiology Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital;Geriatric Department of Beijing North Hospital Of Ordnance Industry;Geriatric Emergency Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital;Geriatric Health Care Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital;Laboratory Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital;Neurology Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital;Peking University Health Science Centre, School of Public Health;

关键词: Sarcopenia;    Cognitive function;    Oldest old;    Muscle strength;    Gait speed;   

DOI  :  10.1186/s12877-021-02190-1

来源: DOAJ

【 摘 要 】

Abstract Background This study aimed to investigate the associations of sarcopenia and its defining components with cognitive function in community-dwelling oldest old (over 80 years old) in China. Methods Sarcopenia was diagnosed by the 2019 Asian Working Group for Sarcopenia (AWGS) criteria. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Logistic and linear regression models were used to explore the associations of sarcopenia and its defining components with risk of mild cognitive impairment (MCI), and performance on multiple cognitive domains among 428 adults aged 80 years and older. Results The overall prevalence of sarcopenia was 35.5%, with 40.34% for men and 32.14% for women. The prevalence of MCI was higher among sarcopenic oldest old than non-sarcopenic oldest old (28.95% vs. 17.39%, p = 0.005). Multivariate logistic regression analyses showed that sarcopenia [odds ratio (OR) = 1.86, 95% confidence interval (CI): 1.04–3.33], low handgrip strength (HS) [OR = 2.33, 95% CI: 1.40–3.87] and slow gait speed (GS) [OR = 2.31, 95% CI: 1.13–4.72] were significantly and independently associated with risk of MCI. Multivariate linear regression analyses showed that low HS was associated with worse performance in global cognitive function, visuospatial and executive function, naming and delayed recall. Conclusions Sarcopenia, low HS and low GS was significantly associated with MCI in community-dwelling oldest old. The associations between sarcopenia and its defining components with different cognitive subdomains could be further explored in the future.

【 授权许可】

Unknown