Concomitant Prostate Cancer and Hodgkin Lymphoma: A Differential Diagnosis Guided by a Combined 68Ga-PSMA-11 and 18F-FDG PET/CT Approach

Medicina

Francesca D’Amico¹  Silvia Morbelli¹  Alberto Miceli¹  Maria Isabella Donegani¹  Marco Mora²  Bruno Spina²  Nataniele Piol²  Matteo Bauckneht³  Mattia Riondato³ 

[1] Department of Health Sciences (DISSAL), University of Genova, 16132 Genova, Italy;Division of Pathology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy;Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy;

关键词: PSMA PET/CT;    FDG PET/CT;    prostate cancer;    Hodgkin lymphoma;   

DOI  :  10.3390/medicina57090975

来源: DOAJ

【 摘 要 】

Here we report the case of concomitant favorable-risk prostate cancer and Hodgkin Lymphoma in a 38-year old male. 68Ga-Prostate Specific Membrane Antigen-11 Positron Emission Tomography/Computed Tomography (68Ga-PSMA-11 PET/CT) was performed for staging purposes, showing the focal PSMA prostatic uptake as well as the presence of enlarged low-PSMA expressing mediastinal lymphadenopathies, thus raising the suspicion of another malignancy. A subsequent 18F-Fluorodeoxyglucose (18F-FDG) PET/CT demonstrated a high FDG-avidity by mediastinal lymphadenopathies as opposed to the low prostate cancer FDG uptake. Of note, both tumor entities were clearly detected by the two scans. However, different ranges in terms of Maximum Standardized Uptake Value (SUVmax) uptake allowed the discrimination between the two tumor entities. At the subsequent mediastinal lymph nodal biopsy, the coexistence of Hodgkin lymphoma was documented. The present case suggests that even if specific for prostate cancer, 68Ga-PSMA-11 PET/CT may raise the suspicion of other concurrent malignancies thanks to its non-receptor bounding mechanism. Further, it shows that in certain cases, the combination of 18F-FDG and 68Ga-PSMA PET/CT imaging may non-invasively guide the clinical management, optimizing the diagnostic process and the subsequent therapeutic interventions.

【 授权许可】

Unknown