A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Heliyon

Miracle Ebubechi Uche¹  Okezie Emmanuel¹  Rachel Oluchukwu Nnanna¹  Eziuche Amadike Ugbogu¹  Grace Oka Agi²  Victor Chibueze Ude³  Celestine Nwabu Ekweogu⁴  Chibuike Ibe⁵  Ositadinma Chinyere Ugbogu⁵ 

[1] Department of Biochemistry, Abia State University, PMB 2000, Uturu, Abia State, Nigeria;Department of Human Nutrition and Dietetics, University of Ibadan, Nigeria;Department of Medical Biochemistry, College of Medicine Enugu State University of Science and Technology, PMB 01660, Enugu, Nigeria;Department of Medical Biochemistry, Imo State University, PMB 2000, Owerri, Imo State, Nigeria;Department of Microbiology, Abia State University, Uturu, PMB 2000, Uturu, Abia State, Nigeria;

关键词: Essential oil;    Ocimum gratissimum;    Pharmacological activities;    Phytochemicals;    Traditional uses;   

DOI  :  

来源: DOAJ

【 摘 要 】

In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum. The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum, further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.

【 授权许可】

Unknown