Approaches to Targeting Bacterial Biofilms in Cystic Fibrosis Airways

International Journal of Molecular Sciences

Valerie Waters¹  Isaac Martin²  Hartmut Grasemann² 

[1] Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada;Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada;

关键词: Pseudomonas aeruginosa;    biofilm matrix;    anti-biofilm;    exopolysaccharides;    adjunctive therapies;    antimicrobial resistance;   

DOI  :  10.3390/ijms22042155

来源: DOAJ

【 摘 要 】

The treatment of lung infection in the context of cystic fibrosis (CF) is limited by a biofilm mode of growth of pathogenic organisms. When compared to planktonically grown bacteria, bacterial biofilms can survive extremely high levels of antimicrobials. Within the lung, bacterial biofilms are aggregates of microorganisms suspended in a matrix of self-secreted proteins within the sputum. These structures offer both physical protection from antibiotics as well as a heterogeneous population of metabolically and phenotypically distinct bacteria. The bacteria themselves and the components of the extracellular matrix, in addition to the signaling pathways that direct their behaviour, are all potential targets for therapeutic intervention discussed in this review. This review touches on the successes and failures of current anti-biofilm strategies, before looking at emerging therapies and the mechanisms by which it is hoped they will overcome current limitations.

【 授权许可】

Unknown