Molecules | |
Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines | |
TatianaTakahasi Komoto1  TaynáMinervina Bernardes1  ThaísBalthazar Mesquita1  AnaLúcia Fachin1  LuisFelipe Buso Bortolotto1  Gabriel Silva1  TamiresAparecida Bitencourt1  Mozart Marins1  SeungJoon Baek2  | |
[1] Biotechnology Unit, University of Ribeirão Preto, SP, Av. Costábile Romano, 2201, Ribeirão Preto, SP, CEP 14096-900, Brazil;Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA; | |
关键词: flavonoids; BT-20; MCF-7; metastasis; MDR; | |
DOI : 10.3390/molecules23082018 | |
来源: DOAJ |
【 摘 要 】
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.
【 授权许可】
Unknown