Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

Molecules

TatianaTakahasi Komoto¹  TaynáMinervina Bernardes¹  ThaísBalthazar Mesquita¹  AnaLúcia Fachin¹  LuisFelipe Buso Bortolotto¹  Gabriel Silva¹  TamiresAparecida Bitencourt¹  Mozart Marins¹  SeungJoon Baek² 

[1] Biotechnology Unit, University of Ribeirão Preto, SP, Av. Costábile Romano, 2201, Ribeirão Preto, SP, CEP 14096-900, Brazil;Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA;

关键词: flavonoids;    BT-20;    MCF-7;    metastasis;    MDR;   

DOI  :  10.3390/molecules23082018

来源: DOAJ

【 摘 要 】

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.

【 授权许可】

Unknown