Effect of Silver Nanoparticles on Blue Light Phototoxicity against Fusobacterium nucleatum

Biophysica

Nir Sterer¹  Shiri Livne¹  Arkadi Rahmanov¹  Uziel Jeffet¹ 

[1] Department of Prosthodontics, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv-Yafo 69978, Israel;

关键词: Fusobacterium nucleatum;    blue light;    silver nanoparticles;   

DOI  :  10.3390/biophysica1040029

来源: DOAJ

【 摘 要 】

A previous study showed that sub-lethal exposure of blue light caused cell membrane damage in Fusobacterium nucleatum (Fn). The aim of the present study was to test the combined effect of blue light and silver nanoparticles against Fn. Bacterial suspensions were exposed to blue light (400–500 nm) with or without silver nanoparticles (10 nm). Exposed and non-exposed samples were studied for malodor production (Odor judge scores), VSC levels (Halimeter), reactive oxygen species (ROS) production (fluorimeter), and bacterial cell membrane damage (fluorescence microscopy). The results showed that combining blue light exposure and silver nanoparticles significantly reduced malodor and VSC production by Fn concomitant with increased ROS levels and bacterial cell membrane damage. These results suggest that silver nanoparticles may increase blue light phototoxicity against Fn.

【 授权许可】

Unknown