Anti-Inflammatory Flavonolignans from Triticum aestivum Linn. Hull

Applied Sciences

ChangHyun Jin¹  MinJeong Hong¹  Jin-Baek Kim¹  HyeonHwa Park¹  Jisu Park¹  Ah-Reum Han¹  Yun-Seo Kil²  Joo-Won Nam² 

[1] Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeollabuk-do, Jeongeup-si 56212, Korea;College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, Gyeongsan-si 38541, Korea;

关键词: Triticum aestivum;    Poaceae;    flavonolignan;    anti-inflammation;   

DOI  :  10.3390/app10238656

来源: DOAJ

【 摘 要 】

Wheat (Triticum aestivum Linn.; Poaceae) is a very common and important food grain and ranks second in total cereal crop production. A large amount of wheat hull is produced after threshing that, as the non-food part of wheat, is agro-waste, accounting for 15~20% of the wheat. This study aimed at biologically and phytochemically investigating wheat hull for its valorization as a by-product. In our ongoing search for natural product-derived anti-inflammatory agents, T. aestivum hull was evaluated for its nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-activated RAW 264.7 cells, and the phytochemical investigation of the ethyl acetate fraction showing inhibitory effect led to the isolation of a flavone (1) and seven flavonolignans (2–8). Compounds 2–8 have not yet been isolated from Triticum species. All compounds were evaluated for their LPS-induced NO production inhibition, and 1, 2, 4, 6, and 8 exhibited inhibitory effects with IC₅₀ values ranging from 24.14 to 58.95 μM. These results suggest the potential of using T. aestivum hull as a source for producing anti-inflammatory components, enhancing its valorization as a by-product.

【 授权许可】

Unknown