RHO Family GTPases in the Biology of Lymphoma

Cells

Roberto Chiarle¹  Claudia Voena¹ 

[1] Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy;

关键词: RHO family GTPases;    RHOA;    RHOH;    VAV;    mutations;    chromosomal translocations;    lymphoma;   

DOI  :  10.3390/cells8070646

来源: DOAJ

【 摘 要 】

RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical and atypical. Both typical and atypical RHO GTPases are critical transducers of intracellular signaling and have been linked to human cancer. Significantly, both gain-of-function and loss-of-function mutations have been described in human tumors with contradicting roles depending on the cell context. The RAS family of GTPases that also belong to the RAS GTPase superfamily like the RHO GTPases, includes arguably the most frequently mutated genes in human cancers (K-RAS, N-RAS, and H-RAS) but has been extensively described elsewhere. This review focuses on the role of RHO family GTPases in human lymphoma initiation and progression.

【 授权许可】

Unknown