The role of Next-Generation Sequencing in tumoral radiosensitivity prediction

Clinical and Translational Radiation Oncology

Ingeborg Tinhofer¹  Jean-Emmanuel Bibault² 

[1] Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Berlin, Germany;Radiation Oncology Department, Georges Pompidou European Hospital, Assistance Publique – Hôpitaux de Paris, Paris Descartes University, Paris Sorbonne Cité, Paris, France;

关键词: Radiation oncology;    Genomics;    Next-Generation Sequencing;    Radiosensitivity;   

DOI  :  10.1016/j.ctro.2017.03.002

来源: DOAJ

【 摘 要 】

Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.

【 授权许可】

Unknown