NR2F6 as a Prognostic Biomarker in HNSCC

International Journal of Molecular Sciences

Barbara Wollenberg¹  Karl-Ludwig Bruchhage²  Christian Idel²  Dirk Rades³  Sven Perner⁴  Patrick Kuppler⁴  Finn-Ole Paulsen⁴  Julika Ribbat-Idel⁴  Jutta Kirfel⁴  Anne Offermann⁴  Luise Klapper⁴ 

[1] Department of Otorhinolaryngology, MRI Technical University Munich, 81675 Munich, Germany;Department of Otorhinolaryngology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany;Department of Radiation Oncology, University of Luebeck and University Hospital Schleswig-Holstein, 23538 Lübeck, Germany;Institute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, 23538 Luebeck, Germany;

关键词: HNSCC;    NR2F6;    local recurrence;    prognosis;    recurrence-free survival;    biomarker;   

DOI  :  10.3390/ijms21155527

来源: DOAJ

【 摘 要 】

Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for patients. NR2F6 has been identified as an immune checkpoint molecule in tumor-infiltrating T lymphocytes and is associated with a poor prognostic outcome in various cancers. The prognostic value of NR2F6 in HNSCC has not been described yet. We used a large, representative and clinically well-characterized cohort of 383 HNSCC patients, of which 22.4% developed a local recurrence. The NR2F6 expression was analyzed by using immunohistochemistry and was afterward correlated with clinical characteristics and clinicopathological features of HNSCC patients. Primary tumors from patients who develop a local recurrence have a higher NR2F6 expression than primary tumors which do not develop a local recurrence. Furthermore, a high NR2F6 expression is associated with poorer recurrence-free survival, although there is no correlation with overall survival. NR2F6 expression is independent of the T stage and UICC stage. NR2F6 might be a new prognostic biomarker for the early detection of local recurrences in HNSCC patients. Therefore, it may help to improve the recognition of patients who would benefit from more frequent follow-up examinations.

【 授权许可】

Unknown