Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Nature Communications

Daming Zuo¹  Huanfa Yi¹  Chunqing Guo¹  Xiang-Yang Wang¹  Wei Zhang²  Yongfu Wang²  Ping Wang³  Xiaoying Zhang³  Fanlei Hu³  Mingxin Bai³  Jianping Guo³  Yin Su³  Xin Li³  Ru Li³  Yang Xie³  Jing Song³  Jimeng Xue³  Yingni Li³  Hua Ye³  Xiang Jiang³  Yuan Jia³  Limin Ren³  Zhanguo Li³  Xi Zheng³  Fei Huang³  Xiangyu Fang³  Xu Liu³  Yan Du⁴  Huaxiang Wu⁴  Shixian Chen⁵  Juan Li⁵  Liang Liu⁶  Hudan Pan⁶ 

[1] Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine;Department of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity;Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135);Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine;Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University;State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology;

DOI  :  10.1038/s41467-020-15700-3

来源: DOAJ

【 摘 要 】

Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.

【 授权许可】

Unknown