Overview of Monogenic or Mendelian Forms of Hypertension

Frontiers in Pediatrics

Nikhil R. Nair²  Harshesh Amin³  Yeshwanter Radhakrishnan⁴  Abhijit Das⁵  Vinod Krishnappa⁵  Rupesh Raina⁷  Kirsten Kusumi⁷ 

[1] Akron Nephrology Associates, Cleveland Clinic Akron General, Akron, OH, United States;Department of Biochemistry, Case Western Reserve University, Cleveland, OH, United States;Department of Internal Medicine, Carolinas Health Care System Blue Ridge, Morganton, NC, United States;Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, United States;Department of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States;Department of Nephrology, Cleveland Clinic Akron General, Akron, OH, United States;Department of Pediatric Nephrology, Akron Children's Hospital, Akron, OH, United States;

关键词: monogenic hypertension;    Liddle syndrome;    congenital adrenal hyperplasia;    apparent mineralocorticoid excess;    Gordon syndrome;    familial hyperaldosteronism;   

DOI  :  10.3389/fped.2019.00263

来源: DOAJ

【 摘 要 】

Monogenic or Mendelian forms of hypertension are described as a group of conditions characterized by insults to the normal regulation of blood pressure by the kidney and adrenal gland. These alterations stem from single mutations that lead to maladaptive overabsorption of electrolytes with fluid shift into the vasculature, and consequent hypertension. Knowledge of these various conditions is essential in diagnosing pediatric or early-onset adult hypertension as they directly affect treatment strategies. Precise diagnosis with specific treatment regimens aimed at the underlying physiologic derangement can restore normotension and prevent the severe sequelae of chronic hypertension.

【 授权许可】

Unknown