HIV-1 Entry, Inhibitors, and Resistance

Viruses

关键词: HIV-1;    envelope;    gp120;    V3 loop;    gp41;    CCR5;    maraviroc;    vicriviroc;   

DOI  :  10.3390/v2051069

来源: DOAJ

【 摘 要 】

Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance.

【 授权许可】

Unknown