Conservative Approach in a Patient with Cervical Intraepithelial Neoplasia Type-3 in Pregnancy: Impact on Disease Progression and Pregnancy Outcome

Journal of Clinical and Diagnostic Research

Pradip Kumar Saha¹  Garima Sachdeva²  Pranab Dey³  Rashmi Bagga³  Jaswinder Kaur Kalra³ 

[1] Additional Professor, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, India.;Junior Resident, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Delhi, India.;Professor, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, India.;

关键词: cervical intraepithelial neoplasia;    colposcopy;    conization;    high-grade squamous intraepithelial lesion;   

DOI  :  10.7860/JCDR/2018/37597.12248

来源: DOAJ

【 摘 要 】

Treatment strategy of Cervical Intraepithelial Neoplasia-3 (CIN 3) in background of High Grade Squamous Intraepithelial Lesion (HSIL) is very different amongst the pregnant and non-pregnant women. This case report highlights the approach of diagnosis and management of CIN 3 in pregnancy. A 32-year-old woman, Fourth Gravida one Live issue and previous 2 Abortion (G4P1021), was diagnosed to have cervical intra-epithelial neoplasia (CIN 3) in pregnancy at 20+1 weeks period of gestation. The decision to continue pregnancy was made. She was followed with LBC and colposcopy 12 weekly during the pregnancy. Her pregnancy was uneventful. She delivered vaginally a live born girl, 2.74 kg at 38+4 weeks. In the postpartum period repeat, Liquid Based Cytology (LBC) and colposcopy-directed biopsy were done. The LBC revealed HSIL while biopsy was suggestive of CIN 3. Cone biopsy was done and histopathology report revealed CIN 3 with margins and tips of cone free of tumour. Thus, in this patient neither progression nor regression was noted with conservative approach and definitive management was deferred until the post-partum period. The aim of this article is to highlight the approach of diagnosis and management of CIN 3 in pregnancy.

【 授权许可】

Unknown