Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network

Journal of Clinical Medicine

Marie Sarabusky¹  Subrata Chakrabarti²  Saumik Biswas² 

[1] Department of Optometry and Vision Science, University of Waterloo, Waterloo, ON N2L3G1, Canada;Department of Pathology and Laboratory Medicine, Western University, London, ON N6A5A5, Canada;

关键词: diabetic retinopathy;    inflammation;    lncRNAs;    epigenetics;    histone modifications;    DNA methylation;    miRNAs;   

DOI  :  10.3390/jcm8071033

来源: DOAJ

【 摘 要 】

Diabetic retinopathy (DR) is reaching epidemic levels globally due to the increase in prevalence of diabetes mellitus (DM). DR also has detrimental effects to quality of life, as it is the leading cause of blindness in the working-age population and the most common cause of vision loss in individuals with DM. Over several decades, many studies have recognized the role of inflammation in the development and progression of DR; however, in recent years, accumulating evidence has also suggested that non-coding RNAs, especially long non-coding (lncRNAs), are aberrantly expressed in diabetes and may play a putative role in the development and progression of DR through the modulation of gene expression at the transcriptional, post-transcriptional, or epigenetic level. In this review, we will first highlight some of the key inflammatory mediators and transcription factors involved in DR, and we will then introduce the critical roles of lncRNAs in DR and inflammation. Following this, we will discuss the implications of lncRNAs in other epigenetic mechanisms that may also contribute to the progression of inflammation in DR.

【 授权许可】

Unknown