Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death

Viruses

KateE. Lawlor¹  Gabriel Laghlali¹  MichelleD. Tate¹ 

[1] Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia;

关键词: Influenza A virus;    cell death;    inflammation;    pathogenesis;   

DOI  :  10.3390/v12040401

来源: DOAJ

【 摘 要 】

Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection.

【 授权许可】

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