Biological Characterization and Clinical Value of OAS Gene Family in Pancreatic Cancer

Frontiers in Oncology

Jia-Lei Li¹  Li-Juan Gao¹  Rui-Rui Yang¹  Xia Cao¹  Zhong-Mei He¹  Min Yan¹  Ji-Min Cao¹ 

[1] Department of Physiology, Shanxi Medical University, Taiyuan, China;Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, China;

关键词: pancreatic cancer;    OAS gene family;    prognosis;    immune infiltration;    biomarker;   

DOI  :  10.3389/fonc.2022.884334

来源: DOAJ

【 摘 要 】

BackgroundOAS gene family plays an important role in antiviral process, but its role in pancreatic cancer has not yet been studied.MethodsWe analyzed the expression, prognostic value and biological function of the OAS gene family in human pancreatic cancer through comprehensive bioinformatic analysis and cellular level validation.ResultsOAS family was highly expressed in pancreatic cancer, and this high expression significantly affected the clinical stage and prognosis of the tumor. OAS gene family was closely related to the immune infiltration of pancreatic cancer, especially neutrophils and dendritic cells, and many immune-related factors and pathways are enriched in the tumor, such as type I interferon signaling pathway and NOD-like receptor signaling pathway.ConclusionTaken together, high expression of OAS family is closely related to poor prognosis of pancreatic cancer. OAS gene family may serve as the biomarker and even therapeutic target of pancreatic cancer.

【 授权许可】

Unknown