A comparative study of intravenous patient-controlled analgesia with tramadol alone and tramadol plus dexmedetomidine for major lower abdominal surgery

Indian Journal of Pain

关键词: Dexmedetomidine;    patient-controlled analgesia;    postoperative analgesia;    tramadol;   

DOI  :  10.4103/ijpn.ijpn_27_17

来源: DOAJ

【 摘 要 】

Background: Different techniques are used to provide postoperative pain relief to the patients. The patient-controlled analgesia (PCA) has come out as promising option. The main advantage of it is a stable plasma concentration of analgesic drug and the control of medication in patients' hand. Morphine has been used extensively for postoperative analgesia, but almost no respiratory depression makes tramadol equally popular for postoperative analgesia. Alpha-2 agonist-like dexmedetomidine can have additive analgesic effect. The above background was the base of planning this study to evaluate the effect of dexmedetomidine added to tramadol for postoperative analgesia. Materials and Methods: This prospective study was conducted in sixty female patients undergoing lower abdominal surgery. All patients were given spinal anesthesia for surgery. When effect of spinal anesthesia wear off and the patient had verbal rating score (VRS) more than three PCA was started. In Group T, all patients received tramadol 1 mg/kg followed by PCA tramadol. In Group D, all patients received tramadol 1 mg/kg and dexmedetomidine 0.5 mcg/kg followed by PCA having combination of tramadol and dexmedetomidine. VRS for pain, total consumption of tramadol, and side effects were recorded for 24 h postoperatively. Results: VRS for pain was comparable in both the groups. PCA demand and total dose of tramadol were less in group who received tramadol with dexmedetomidine. There was no significant difference in occurrence of side effects. Conclusions: The combination of dexmedetomidine with tramadol reduces the tramadol requirement for postoperative analgesia.

【 授权许可】

Unknown