Zika Virus Antibody Titers Three Years after Confirmed Infection

Viruses

Zéfia Faerber¹  Kajal Phalai¹  Stephen Vreden¹  Erwin de Bruin²  Barry Rockx²  Thomas Langerak²  Louella M. R. Kasbergen²  Felicity Chandler²  Marion P. G. Koopmans²  Tom Brinkman²  Eric C. M. van Gorp²  Sebastian Ulbert³  Alexandra Rockstroh³ 

[1] Department of Internal Medicine, Academic Hospital Paramaribo, Paramaribo, Suriname;Erasmus Medical Center, Department of Viroscience, 3015 GD Rotterdam, The Netherlands;Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany;

关键词: Zika virus;    serology;    cross-reactivity;    dengue virus;    waning immunity;   

DOI  :  10.3390/v13071345

来源: DOAJ

【 摘 要 】

Background: In 2015–2016, a large Zika virus (ZIKV) outbreak occurred in the Americas. Although the exact ZIKV antibody kinetics after infection are unknown, recent evidence indicates the rapid waning of ZIKV antibodies in humans. Therefore, we aimed to determine the levels of ZIKV antibodies more than three years after a ZIKV infection. Methods: We performed ZIKV virus neutralization tests (VNT) and a commercial ZIKV non-structural protein 1 (NS1) IgG ELISA in a cohort of 49 participants from Suriname who had a polymerase-chain-reaction-confirmed ZIKV infection more than three years ago. Furthermore, we determined the presence of antibodies against multiple dengue virus (DENV) antigens. Results: The ZIKV seroprevalence in this cohort, assessed with ZIKV VNT and ZIKV NS1 IgG ELISA, was 59.2% and 63.3%, respectively. There was, however, no correlation between these two tests. Furthermore, we did not find evidence of a potential negative influence of DENV immunity on ZIKV antibody titers. Conclusions: ZIKV seroprevalence, assessed with two commonly used serological tests, was lower than expected in this cohort of participants who had a confirmed previous ZIKV infection. This can have implications for future ZIKV seroprevalence studies and possibly for the duration of immunological protection after a ZIKV infection.

【 授权许可】

Unknown