International Journal of Molecular Sciences | |
Sulforaphane Causes Cell Cycle Arrest and Apoptosis in Human Glioblastoma U87MG and U373MG Cell Lines under Hypoxic Conditions | |
Giulia Sita1  Patrizia Hrelia1  Agnese Graziosi1  Fabiana Morroni1  | |
[1] Department of Pharmacy and BioTechnology—FaBiT, University of Bologna—Alma Mater Studiorum, Via Irnerio 48, 40126 Bologna, Italy; | |
关键词: sulforaphane; hypoxia; glioblastoma; apoptosis; U87MG; U373MG; | |
DOI : 10.3390/ijms222011201 | |
来源: DOAJ |
【 摘 要 】
Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor. The median survival rate from diagnosis ranges from 15 to 17 months because the tumor is resistant to most therapeutic strategies. GBM exhibits microvascular hyperplasia and pronounced necrosis triggered by hypoxia. Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, has already demonstrated the ability to inhibit cell proliferation, by provoking cell cycle arrest, and leading to apoptosis in many cell lines. In this study, we investigated the antineoplastic effects of SFN [20–80
【 授权许可】
Unknown