Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

International Journal of Molecular Sciences

Pascal Pigny¹  Lucie Coppin¹  Nicole Porchet¹  Julie Leclerc¹  Audrey Vincent¹ 

[1] University of Lille, UMR-S 1172-JPARC—Jean-Pierre Aubert Research Center, F-59000 Lille, France;

关键词: mRNA life-cycle;    mRNA fate;    mRNA-binding proteins;    mRNA-binding domains;    intrinsically disordered regions;    low complexity disordered regions;    cytoplasmic RNA granules;    DNA and RNA-binding proteins;    RNA regulon;    galectin-3;   

DOI  :  10.3390/ijms19030650

来源: DOAJ

【 摘 要 】

Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies.

【 授权许可】

Unknown