Tilapia Skin Peptides Ameliorate Diabetic Nephropathy in STZ-Induced Diabetic Rats and HG-Induced GMCs by Improving Mitochondrial Dysfunction

Marine Drugs

Dongxiao Zheng¹  Yingxia Zhang¹  Xi Xie¹  Guanyu Yang¹  Lin Jin¹  Qian Jiang²  Huan Yang³  Wei Li³  Yongjun Chen³ 

[1] Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China;School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China;School of Materials Science and Engineering, Hainan University, Haikou 570228, China;

关键词: fish peptides;    diabetic nephropathy;    lipid metabolism;    renal fibrosis;    mitochondria;    Bnip3/Nix signaling;   

DOI  :  10.3390/md18070363

来源: DOAJ

【 摘 要 】

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes, and mitochondrial dysfunction has been observed in the kidneys of diabetic patients. Tilapia skin peptides (TSPs) are mixtures of small-molecular-weight peptides derived from tilapia skin. Rising evidence suggests that bioactive peptides from marine sources are beneficial for DN. This study aimed to investigate whether TSPs can alleviate the pathological progress in experimental DN by improving mitochondrial dysfunction through the activation of Bnip3/Nix signaling. In the current study, TSPs treatment alleviated the metabolic parameters and renal morphology in streptozotocin-induced diabetic rats. Additionally, TSPs treatment significantly activated Bnip3/Nix signaling and improved the mitochondrial morphology, reversed the over-production of mitochondrial superoxide and cellular reactive oxygen species and the decreased mitochondrial membrane potential, thereby inhibiting the expressions of fibronectin, collagen IV and intercellular cell adhesion molecule-1 in glomerular mesangial cells induced by high glucose. Collectively, our results suggest that TSPs show the renoprotective effect on DN by improving mitochondrial dysfunction, and they can be a potential therapeutic strategy for DN.

【 授权许可】

Unknown