Predictive Factors for Pancreatic Cancer and Its Early Detection Using Special Pancreatic Ultrasonography in High-Risk Individuals

Cancers

Takahiro Tabuchi¹  Suetsumi Okagaki²  Reiko Ashida²  Miho Nakao²  Junko Fukuda²  Kazuhiro Katayama²  Tatsuya Ioka²  Sachiko Tanaka²  Shigenori Nagata³  Hiroyuki Uehara⁴  Takuo Yamai⁴  Kenji Ikezawa⁴  Ryoji Takada⁴  Kazuyoshi Ohkawa⁴  Nobuyasu Fukutake⁴  Hidenori Takahashi⁵ 

[1] Cancer Control Center, Osaka International Cancer Institute, Osaka 541-8567, Japan;Department of Cancer Survey and Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan;Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka 541-8567, Japan;Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan;Department of Surgery, Osaka International Cancer Institute, Osaka 541-8567, Japan;

关键词: special pancreatic US;    MPD growth rate;    early detection;    pancreatic cancer;    IPMN.;   

DOI  :  10.3390/cancers13030502

来源: DOAJ

【 摘 要 】

Because pancreatic cancer has a dismal prognosis, a strategy for early diagnosis is required. This study aimed to identify predictive factors of neoplastic progression in patients at high risk for pancreatic cancer and examined the efficiency of surveillance using transabdominal special ultrasonography focusing on the pancreas (special pancreatic US). Patients with slight main pancreatic duct (MPD) dilatation (≥2.5 mm) and/or pancreatic cysts (≥5 mm) were enrolled in a prospective surveillance study with special pancreatic US in a Japanese cancer referral center. A total of 498 patients undergoing surveillance for ≥3 years were included. During the median follow-up of 5.9 years, neoplastic progression developed in 11 patients (2.2%), including 9 patients who underwent pancreatectomy. Eight patients (72.7%) were diagnosed with stage 0/I disease, with an overall survival duration of 8.8 years. Findings of both MPD dilatation and pancreatic cysts at initial surveillance, MPD growth (≥0.2 mm/year) and cyst growth (≥2 mm/year) during surveillance were identified as independent risk factors for neoplastic progression. In summary, surveillance with special pancreatic US for high-risk individuals contributed to earlier detection of neoplastic progression, leading to a favorable prognosis. During surveillance, attention should be paid to MPD growth as well as to cyst growth.

【 授权许可】

Unknown