Sedative-hypnotic Effect of Ash of Silver in Mice: A Reverse Pharmacological Study

Journal of Traditional and Complementary Medicine

Pawan Kumar¹  Deep Inder² 

[1] Department of Community Health Administration, National Institute of Health and Family Welfare, Munirka, New Delhi, India.;Department of Pharmacology, FOD, Jamia Millia Islamia, New Delhi, India.;

关键词: Ash of silver;    Pentobarbitone;    Sedation;   

DOI  :  10.4103/2225-4110.129198

来源: DOAJ

【 摘 要 】

Ash of silver is used in traditional systems of medicine for various neurological conditions like insomnias, neuralgias, anxiety disorders, and convulsions. The present study was conducted to evaluate the sedative-hypnotic activity of ash of silver in comparison to pentobarbitone (standard drug) in albino mice. The mice were divided into four groups as follows: Group 1 (control): Gum acacia [GA; 1% per os (p.o.)], group 2 (standard): Pentobarbitone [50 mg/kg intraperitoneal (i.p.)], group 3 (test): Ash of silver (50 mg/kg p.o.), and group 4: Ash of silver (50 mg/kg p.o.) given 30 min prior to administration of pentobarbitone (50 mg/kg i.p.). Time of onset, recovery, and total duration of loss of righting reflex were studied. Ash of silver (test) produced significant sedation (P<0.01) compared to control (GA 1%), but the effect was significantly less compared to that of standard pentobarbitone at the doses used. Also, significant potentiation (P<0.001) of the sedative-hypnotic effect of pentobarbitone was observed with the test drug.

【 授权许可】

Unknown