Asymmetric cell division and template DNA co-segregation in cancer stem cells

Frontiers in Oncology

Sharon R Pine¹  Wenyu eLiu¹ 

[1] Rutgers Cancer Institute of New Jersey;

关键词: Asymmetric Cell Division;    Wnt;    cancer stem cells;    Notch;    p53;    immortal DNA;   

DOI  :  10.3389/fonc.2014.00226

来源: DOAJ

【 摘 要 】

During tissue homeostasis, normal stem cells self-renew and repopulate the diverse cell types found within the tissue via a series of carefully controlled symmetric and asymmetric cell divisions. The notion that solid tumors comprise a subset of cancer stem cells with dysregulated self-renewal and excessive symmetric cell divisions has led to numerous studies aimed to elucidate the mechanisms regulating asymmetric cell division under steady-state conditions, during stem cell expansion, and in cancer. In this perspective, we focus on a type of asymmetry that can be established during asymmetric cell division, called non-random co-segregation of template DNA, which has been identified across numerous species, cell types and cancers. We discuss the role of p53 loss in maintaining self-renewal in both normal and malignant cells.We then review our current knowledge of the mechanisms underlying co-segregation of template DNA strands and the stem cell pathways associated with it in normal and cancer stem cells.

【 授权许可】

Unknown