Epigenetic drugs in Alzheimer’s disease

Biomolecular Concepts

Franco Rafael¹  Lucas María Pascual²  García-Osta Ana²  Oyarzabal Julen³ 

[1] ;Cell and Molecular Neuropharmacology, Neurosciences Division, Center for Applied Medical Research, CIMA, University of Navarra, Av. Pio XII 55, E-31008 Pamplona, Spain;Small Molecule Discovery Platform, Center for Applied Medical Research, CIMA, University of Navarra, Av. Pio XII 55, E-31008 Pamplona, Spain;

关键词: amyloid;    histone acetylation;    memory;    tau phosphorylation;   

DOI  :  10.1515/bmc-2013-0012

来源: DOAJ

【 摘 要 】

Epigenetic processes, such as DNA methylation and histone acetylation, regulate the genome-environment interactions that may play important roles in a wide range of brain disorders, including Alzheimer’s disease (AD). Indeed, the role of epigenetic machinery in learning and memory processes is well documented. In this review, we will focus on the most recent literature on tools that target epigenetic mechanisms, particularly on histone acetylation, and we will discuss the use of chemical probes to validate these targets in therapeutic strategies for AD.

【 授权许可】

Unknown