The NIH Extracellular RNA Communication Consortium

Journal of Extracellular Vesicles

Aniruddha Ganguly¹  T. Kevin Howcroft²  Suresh Mohla³  Pothur R. Srinivas⁴  Alexandra M. Ainsztein⁵  Philip J. Brooks⁶  Christine A. Kelley⁷  Matthew Reilly⁸  Max Guo⁹  Sundar Venkatachalam^1,10  Danilo A. Tagle^1,11  Lillian S. Kuo^1,11  Jessica M. Tucker^1,12  John S. Satterlee^1,13  Dena Procaccini^1,13  Margaret Sutherland^1,14  George A. McKie^1,15  Vivien G. Dugan^1,16  Patricia A. Labosky^1,17  Rebecca Lenzi^1,17  Elizabeth Stansell Church^1,18 

[1] Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), Rockville, MD, USA;Division of Cancer Biology, Cancer Immunology, Hematology, and Etiology Branch, National Cancer Institute (NCI), Rockville, MD, USA;Division of Cancer Biology, Tumor Biology and Metastasis Branch (TBMB), National Cancer Institute (NCI), Rockville, MD, USA;Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD, USA;Division of Cell Biology and Biophysics, National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA;Division of Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), Bethesda, MD, USA;Division of Discovery Science and Technology, National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA;Division of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Rockville, MD, USA;Genetics and Cell Biology Branch, Division of Aging Biology, National Institute on Aging (NIA), Bethesda, MD, USA;Integrative Biology and Infectious Diseases Branch, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA;National Center for Advancing Translational Science (NCATS), Bethesda, MD, USA;National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA;National Institute on Drug Abuse (NIDA), Rockville, MD, USA;Neurodegeneration Cluster, National Institute of Neurological Disorders and Stroke (NINDS), Rockville, MD, USA;Ocular Infection, Inflammation, and Immunology, National Eye Institute (NEI), Rockville, MD, USA;Office of Genomics and Advanced Technologies, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA;Office of Strategic Coordination, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), National Institutes of Health (NIH), Bethesda, MD, USA;Pathogenesis and Basic Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA;

关键词: ERCC;    exRNA;    extracellular RNA;   

DOI  :  10.3402/jev.v4.27493

来源: DOAJ

【 摘 要 】

The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.

【 授权许可】

Unknown