ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

International Journal of Molecular Sciences

Stefan Rose-John¹  Neele Schumacher¹  Dirk Schmidt-Arras¹ 

[1] Institute of Biochemistry, Christian-Albrechts-University, 24118 Kiel, Germany;

关键词: ADAM;    protease;    EGFR;    tumour micro-environment;    Notch;    IL-6;   

DOI  :  10.3390/ijms21145133

来源: DOAJ

【 摘 要 】

Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically.

【 授权许可】

Unknown