Posterior reversible encephalopathy syndrome in a woman who used gonadotropin-releasing hormone agonists: a case report

Obstetrics & Gynecology Science

Tae Hee Kim¹  Byung Chul Jee¹  Se Jeong Kim¹  Minhee Lee² 

[1] Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, .Korea;Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, .Korea;

关键词: gonadotropin-releasing hormone;    leuprolide;    brain diseases;    myoma;   

DOI  :  10.5468/ogs.2019.62.1.69

来源: DOAJ

【 摘 要 】

Posterior reversible encephalopathy syndrome (PRES) is a newly described adverse effect possibly associated with gonadotropin-releasing hormone (GnRH) agonist therapy. We report a case of PRES after 2 doses of depot GnRH agonists in a 44-year-old woman with a huge myoma uteri and iron-deficiency anemia. Brain magnetic resonance imaging showed high signal lesions in both occipital lobes on fluid-attenuated inversion-recovery (FLAIR) images, compatible with PRES. After treatment with anticonvulsant, she recovered both radiographically and clinically. The association between PRES and GnRH agonist use is still enigmatic, and thus should be further clarified.

【 授权许可】

Unknown