A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study

Cardiovascular Diabetology

Zhengnan Gao¹  Anping Wang²  Kang Chen²  Wenhua Yan²  Zuojie Luo³  Guijun Qin⁴  Xulei Tang⁵  Binruo Zhu⁶  Yiming Mu⁶  Jie Wang⁶  Weiqing Wang⁷  Qin Wan⁸  Lulu Chen⁹  Li Yan^1,10 

[1] Dalian Central Hospital;Department of Endocrinology, Chinese PLA General Hospital;First Affiliated Hospital of Guangxi Medical University;First Affiliated Hospital of Zhengzhou University;First Hospital of Lanzhou University;Medicine School of Nankai University;Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine;Southwest Medical University Affiliated Hospital;Wuhan Union Hospital, Huazhong University of Science and Technology;Zhongshan University Sun Yat-sen Memorial Hospital;

关键词: TyG index;    HTN;    Lipid parameters;    Glycemic parameters;   

DOI  :  10.1186/s12933-020-01077-6

来源: DOAJ

【 摘 要 】

Abstract Background Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to investigate the association of the TyG index and HTN and to compare the discriminative power of the TyG index, lipid, glycemic parameters for the risk of HTN in elderly individuals. Methods The present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. In total, 47,808 participants were recruited in this cross-sectional study. The TyG index was divided into five groups: the < 20% group, the 20–39% group, the 40–59% group, the 60–79% group and the ≥ 80% group, according to quintile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between the TyG vs. lipid parameters, glycemic parameters and HTN. Results Multivariate logistic regression analysis shows that compared with lipid and glycemic parameters, the TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18–1.51, p < 0.0001 in total subjects; OR 1.39, 95% CI 1.11–1.74, p = 0.0042 in men; OR 1.28, 95% CI 1.11–1.49, p = 0.0010 in women). In a stratified analysis, an elevated TyG index is significantly associated with HTN in the subgroup of the oldest age (≥ 65) (OR 1.67, 95% CI 1.30–2.14, p < 0.0001), as well as with obesity (Body mass index (BMI) ≥ 28 kg/m2) (OR 1.85, 95% CI 1.29–2.66, p = 0.0009) or lower estimated glomerular filtration rate (eGFR) (< 90 mL/(min·1.73 m2)) (OR 1.72, 95% CI 1.33–2.21, p < 0.0001). Conclusion The TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.

【 授权许可】

Unknown