Comparative assessment of a glomerular filtration rate on creatinine and cystatin C in patients with the decompensated clinical course of cirrhosis

ScienceRise

Дмитрий Иванович Михантьев¹  Евгений Игоревич Баранов²  Алексей Николаевич Петраш³  Вячеслав Васильевич Нешта³  Виктор Николаевич Антоневич³  Алий Саитович Тугушев⁴ 

[1] Sedov St., 3, Zaporozhye, Ukraine, 69035;Municipal management «City clinical hospital emergency and emergency medical service»Pobedy St., 80, Zaporozhye, 69005;SD «Local clinical hospital on the station Zaporozhye-2 of the Pridneprovsky railway»Chumachenko St., 21, Zaporozhye, Ukraine, 69104;Zaporozhye state medical university;

关键词: cirrhosis;    renal dysfunction;    creatinine;    cystatin C;    glomerular filtration rate;   

DOI  :  10.15587/2313-8416.2015.47171

来源: DOAJ

【 摘 要 】

An inalienable part of the natural clinical course of cirrhosis that defines its severity is the development of the renal dysfunction.  But the principles of diagnostics of the renal dysfunction are not defined in full for today. The level of the serum cystatin C is assumed as the most objective marker of the decrease of the renal function for today.

Aim of research. To carry out the comparative assessment of the glomerular filtration rate (GFR) on creatinine and cystatin C in patients with the complicated clinical course of cirrhosis depending on the positive or negative result of treatment – they were discharged from hospital or dead.   

Material and methods. 190 patients with cirrhosis were under observation: 123 had a gastrointestinal bleeding, 67 – refractory ascites.84 patients dead during observation. The duration of observation was from 2weeks to 2,5-3 years.

The glomerular filtration rate was defined on the clearance of endogenous creatinine of the blood and urine in all patients at admission to hospital. The level of the serum cystatin C was simultaneously defined in 80 patients.

Results of research. Whereas in patients with gastrointestinal bleeding the decrease of GFR on creatinine was in 78,6 % at admission, in patients with refractory ascites the similar indicators were only in 41,3%. According to the level of the serum cystatin C the decrease of GFR at admission was noticed in 90,6% of patients with gastrointestinal bleeding and in 98,5% with diuretic-resistant ascites. Among the dead patients the decrease of GFR on cystatin C took place practically in all patients. At the same time in most of them the glomerular filtration rate was lower than 60 ml\min.  

Conclusions. The level of the serum cystatin C is a most informative criterion of assessment of the renal dysfunction and it can be used as a criterion of efficiency of treatment and prognosis of the clinical course

【 授权许可】

Unknown