A reanalysis of Cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild Alzheimer's disease dementia and depression

Frontiers in Psychology

Rafaela Teixeira Avila¹  Marco Tulio G Cintra¹  Marco Aurelio Romano-Silva¹  Maria Aparecida Bicalho¹  Breno Satler Diniz¹  Jonas Jardim de Paula¹  Leandro Fernandes Malloy-Diniz¹ 

[1] Universidade Federal de Minas Gerais;

关键词: Activities of Daily Living;    Depression;    Mild Cognitive Impairment;    neuropsychological assessment;    Alzheimer’s disease;    cognitive assessment;   

DOI  :  10.3389/fpsyg.2015.02061

来源: DOAJ

【 摘 要 】

Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer’s disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N=274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.

【 授权许可】

Unknown