PTEN at the crossroad of metabolic diseases and cancer in the liver

Annals of Hepatology

Michelangelo Foti¹  Manlio Vinciguerra² 

[1] EMBL Mouse Biology Unit, Monterotondo, Rome, Italy;Dept. Cellular Physiology and Metabolism, Geneva Medical Faculty, Geneva, Switzerland;

关键词: PTEN;    insulin resistance;    metabolic syndrome;    obesity;    non-alcoholic fatty liver diseases;    steatosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases.

【 授权许可】

Unknown