Sialic Acid—Modified Nanoparticles—New Approaches in the Glioma Management—Perspective Review

International Journal of Molecular Sciences

Halina Car¹  Przemyslaw Wielgat¹  Katarzyna Niemirowicz-Laskowska²  Agnieszka Z. Wilczewska³ 

[1] Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland;Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-265 Bialystok, Poland;Division of Chemistry, University of Bialystok, Ciołkowskiego 1K, 15-245 Bialystok, Poland;

关键词: sialic acid;    nanoparticles;    Siglecs;    blood–brain barrier;    glioma;   

DOI  :  10.3390/ijms22147494

来源: DOAJ

【 摘 要 】

The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior and correlates with worse prognosis. Better understanding of the role of sialylation in cellular and molecular processes opens a new way in the development of therapeutic tools for human brain tumors. According to the recent clinical observation, the cellular heterogeneity, activity of brain cancer stem cells (BCSCs), immune evasion, and function of the blood–brain barrier (BBB) are attractive targets for new therapeutic strategies. In this review, we summarize the importance of sialic acid-modified nanoparticles in brain tumor progression.

【 授权许可】

Unknown