Research Progress of circRNAs in Head and Neck Cancers

Frontiers in Oncology

Kunjie Zhu¹  Panchun Li²  Zhaojian Gong²  Lei Shi³  Shanshan Zhang⁴  Xianjie Jiang⁵  Xiangying Deng⁵  Zhaoyang Zeng⁵  Wenling Zhang⁵  Can Guo⁵  Yongzhen Mo⁵  Guiyuan Li⁵  Wei Xiong⁵ 

[1] Department of Head and Neck Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Stomatology, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, China;NHC Key Laboratory of Carcinogenesis, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, China;

关键词: circRNA;    non-coding RNA;    biomarker;    head and neck cancer;    miRNA sponge;   

DOI  :  10.3389/fonc.2021.616202

来源: DOAJ

【 摘 要 】

Circular RNAs (circRNAs) are a novel type of non-coding RNAs. Because of their characteristics of a closed loop structure, disease- and tissue-specificity, and high conservation and stability, circRNAs have the potential to be biomarkers for disease diagnosis. Head and neck cancers are one of the most common malignant tumors with high incidence rates globally. Affected patients are often diagnosed at the advanced stage with poor prognosis, owing to the concealment of anatomic sites. The characteristics, functions, and specific mechanisms of circRNAs in head and neck cancers are increasingly being discovered, and they have important clinical significance for the early diagnosis, treatment, and prognosis evaluation of patients with cancer. In this study, the generation, characteristics, and functions of circRNAs, along with their regulatory mechanisms in head and neck cancers have been summarized. We report that circRNAs interact with molecules such as transcription and growth factors to influence specific pathways involved in tumorigenesis. We conclude that circRNAs have an important role to play in the proliferation, invasion, metastasis, energy and substance metabolism, and treatment resistance in cancers.

【 授权许可】

Unknown